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CS-W001157 4
Total: USD 88.00

2-Morpholino-5-(trifluoromethyl)aniline

  • CAS No. 784-57-6

  • Cat. No. CS-0157123
  • Purity≥98%
  • MDL No.MFCD00042160

*For research and further manufacturing use only, not for direct human use.

2-Morpholino-5-(trifluoromethyl)aniline|CS-0157123

Structure of 784-57-6

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General Information

  • CAS No. 784-57-6
  • Cat. No. CS-0157123
  • Purity ≥98%
  • MDL No. MFCD00042160
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃F₃N₂O
  • Molecular Weight 246.23
  • Synonym(s) 2-(4-Morpholinyl)-5-(Trifluoromethyl)Aniline
  • SMILES C1=CC(=C(C=C1C(F)(F)F)N)N2CCOCC2

Description

2-Morpholino-5-(trifluoromethyl)aniline features a morpholino group attached to an electron-deficient aniline scaffold, enabling strong π-stacking and hydrogen-bonding interactions. This trifluoromethyl-substituted aryl amine integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and membrane permeability under standard conditions.

Application

2-Morpholino-5-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the morpholine moiety provides hydrogen-bonding capacity and solubility. The compound exhibits good bench stability and functions effectively in standard coupling reactions, facilitating efficient construction of complex scaffolds under routine conditions.

Synthesis

  • Route1
    • 4-[2-Nitro-4-(trifluoromethyl)phenyl]morpholine|CS-0206473
      62054-72-2
    • ~92%
    • In-stock
      2-Morpholino-5-(trifluoromethyl)aniline|CS-0157123
      784-57-6

    References

    • EP1712242 A1, ; Page/Page column 35 ;
  • Route2
    • null|null
      121-17-5
    • ~%
    • In-stock
      2-Morpholino-5-(trifluoromethyl)aniline|CS-0157123
      784-57-6

    References

    • Kogyo Kagaku Zasshi, , vol. 62, p. 706,708 Chem. Zentralbl., , vol. 131, p. 7854

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302+H312-H315-H319-H331-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.49
  • LogP   2.1242
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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