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CS-W001157 4
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tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate

  • CAS No. 781649-86-3

  • Cat. No. CS-M0488
  • Purity≥98%
  • MDL No.MFCD13184780
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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate|CS-M0488

Structure of 781649-86-3

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Description

tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate features a piperidine scaffold bearing a pyridinamine handle, enabling direct conjugation in late-stage functionalization. The tert-butyl ester offers bench-stable protection, simplifying purification and handling during synthetic workflows. This building block integrates efficiently into kinase inhibitor scaffolds and other bioactive heterocycles.

Application

tert-Butyl 4-((2-aminopyridin-3-yl)amino)piperidine-1-carboxylate serves as a versatile building block for pyridine-containing heterocycles, enabling efficient access to bioactive scaffolds via standard amide coupling, Suzuki-Miyaura, and Buchwald-Hartwig reactions. The protected amine and piperidine core offer excellent functional group tolerance, bench stability, and ease of purification, making it ideal for medicinal chemistry campaigns and API intermediate synthesis.

General Information

  • CAS No. 781649-86-3
  • Cat. No. CS-M0488
  • Purity ≥98%
  • MDL No. MFCD13184780
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₄N₄O₂
  • Molecular Weight 292.38
  • Synonym(s) 1-Piperidinecarboxylic acid, 4-[(2-aMino-3-pyridinyl)aMino]-, 1,1-diMethylethyl ester
  • SMILES O=C(OC(C)(C)C)N(CC1)CCC1NC2=CC=CN=C2N

Computational Chemistry Data

  • TPSA   80.48
  • LogP   2.4752
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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