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CS-W001157 4
Total: USD 88.00

1-Ethynylcyclohexanol

  • CAS No. 78-27-3

  • Cat. No. CS-W011179
  • Purity≥97%
  • MDL No.MFCD00003858

*For research and further manufacturing use only, not for direct human use.

1-Ethynylcyclohexanol|CS-W011179

Structure of 78-27-3

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General Information

  • CAS No. 78-27-3
  • Cat. No. CS-W011179
  • Purity ≥97%
  • MDL No. MFCD00003858
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂O
  • Molecular Weight 124.18
  • Synonym(s) (1-Hydroxycyclohexyl)ethyne
  • SMILES OC1(C#C)CCCCC1

Description

TAMRA-PEG3-biotin is a fluorescent biotinylation linker for bioconjugation. The hydrophilic PEG spacer increases aqueous solubility.

Application

1-Ethynylcyclohexanol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized cyclohexyl scaffolds via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and other transition-metal-mediated coupling reactions. The terminal alkyne functionality offers high reactivity in click chemistry applications, while the hydroxyl group provides a handle for selective derivatization or protection. Bench-stable and compatible with a range of reaction conditions, it facilitates rapid assembly of complex molecular architectures in medicinal chemistry and materials science workflows.

Synthesis

  • Route1
    • null|null
      108-94-1
    • null|null
      4301-14-8
    • ~79%
    • In-stock
      1-Ethynylcyclohexanol|CS-W011179
      78-27-3

    References

    • WO2006/7703 A1, ; Page/Page column 28 ;
  • Route2
    • null|null
      42969-66-4
    • ~84%
    • In-stock
      1-Ethynylcyclohexanol|CS-W011179
      78-27-3

    References

    • European Journal of Organic Chemistry, , # 19 p. 3827 - 3831
  • Route3
    • null|null
      108-94-1
    • null|null
      74-86-2
    • ~99%
    • In-stock
      1-Ethynylcyclohexanol|CS-W011179
      78-27-3

    References

    • Heterocycles, , vol. 63, # 7 p. 1637 - 1643

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H311-H315-H319
Precautionary Statements : P264-P270-P280

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.3148
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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