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CS-W001157 4
Total: USD 88.00

5-Bromo-2-methylpyrimidine

  • CAS No. 7752-78-5

  • Cat. No. CS-W004845
  • Purity≥98%
  • MDL No.MFCD07375143

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-methylpyrimidine|CS-W004845

Structure of 7752-78-5

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General Information

  • CAS No. 7752-78-5
  • Cat. No. CS-W004845
  • Purity ≥98%
  • MDL No. MFCD07375143
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BrN₂
  • Molecular Weight 173.01
  • Synonym(s) 5-Bromo-2-methyl-Pyrimidine
  • SMILES BrC1=CN=C(N=C1)C

Description

5-Bromo-2-methylpyrimidine serves as a key heterocyclic scaffold for medicinal chemistry and agrochemical synthesis. The bromine at the 5-position enables efficient cross-coupling reactions, while the methyl group enhances solubility and modulates electronic properties. This bench-stable compound integrates readily into complex molecular architectures under standard conditions.

Application

5-Bromo-2-methylpyrimidine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine substituent. The methyl group at the 2-position enhances electronic stability and facilitates selective functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing pharmaceutically relevant pyrimidine scaffolds and advanced intermediates in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • WO2011/130628 A1, ; Page/Page column 176 ; WO 2011/130628 A1
  • Route2
    • null|null
      75-24-1
    • In-stock
      5-Bromo-2-iodopyrimidine|CS-D0840
      183438-24-6
    • ~%
    • In-stock
      5-Bromo-2-methylpyrimidine|CS-W004845
      7752-78-5

    References

    • US2004/110785 A1, ; Page 124 ;
  • Route3
    • null|null
      544-97-8
    • In-stock
      5-Bromo-2-iodopyrimidine|CS-D0840
      183438-24-6
    • ~%
    • In-stock
      5-Bromo-2-methylpyrimidine|CS-W004845
      7752-78-5

    References

    • WO2009/134668 A2, ; Page/Page column 29 ; WO 2009/134668 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.54752
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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