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CS-W001157 4
Total: USD 88.00

5-(Hydroxymethyl)-2-iodophenol

  • CAS No. 773869-57-1

  • Cat. No. CS-W018963
  • Purity≥98%
  • MDL No.MFCD06202863

*For research and further manufacturing use only, not for direct human use.

5-(Hydroxymethyl)-2-iodophenol|CS-W018963

Structure of 773869-57-1

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General Information

  • CAS No. 773869-57-1
  • Cat. No. CS-W018963
  • Purity ≥98%
  • MDL No. MFCD06202863
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇IO₂
  • Molecular Weight 250.03
  • Synonym(s) Benzenemethanol, 3-hydroxy-4-iodo-
  • SMILES OC1=CC(CO)=CC=C1I

Description

5-(Hydroxymethyl)-2-iodophenol features a phenolic hydroxyl group paired with a para-iodinated aromatic ring and a reactive hydroxymethyl side chain. This trifunctional scaffold enables direct coupling in cross-coupling reactions, bioconjugation, or polymer functionalization under mild conditions. The iodide serves as a versatile handle for palladium-catalyzed transformations, while the hydroxymethyl moiety supports derivatization via oxidation or etherification. The molecule exhibits good stability and solubility in common organic solvents, facilitating use in synthetic workflows requiring precise functional group control.

Application

5-(Hydroxymethyl)-2-iodophenol serves as a versatile building block for the synthesis of functionalized heterocycles and pharmaceutical intermediates. The ortho-iodo and hydroxymethyl groups enable palladium-catalyzed cross-coupling reactions and selective derivatization, while the phenolic OH supports further functionalization. Its bench-stable nature and compatibility with standard protecting group strategies facilitate efficient synthetic planning in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Takeda Pharmaceutical Company Limited Patent: EP2351743 A1, 2011 ; Location in patent: Page/Page column 117 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.4891
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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