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CS-W001157 4
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2,2-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

  • CAS No. 866089-28-3

  • Cat. No. CS-0111723
  • Purity≥97%
  • MDL No.MFCD11603419

*For research and further manufacturing use only, not for direct human use.

2,2-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine|CS-0111723

Structure of 866089-28-3

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General Information

  • CAS No. 866089-28-3
  • Cat. No. CS-0111723
  • Purity ≥97%
  • MDL No. MFCD11603419
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO
  • Molecular Weight 163.22
  • Synonym(s) 2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazine
  • SMILES CC1(C)OC2=CC=CC=C2NC1

Description

E3 ligase ligand-linker conjugate, Thalidomide-O-PEG2-NHS ester, is synthesized compound that incorporatess the Thalidomide based cereblon ligand and the PEG linker used in PROTAC technology.

Synthesis

  • Route1
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    • ~%
    • In-stock
      2,2-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine|CS-0111723
      866089-28-3

    References

    • NOVARTIS AG; BEBERNITZ, Gregory, Raymond; BOCK, Mark, G.; REDDY, Dumbala Srinivas; HAJARE, Atul Kashinath; VYAVAHARE, Vinod; BHOSALE, Sandeep Bhausaheb; KURHADE, Suresh Eknath; SALUNKHE, Videsh; SHAIKH, Nadim, S.; BHUNIYA, Debnath; PALLE, P., Venkata; FENG, Lili; LIANG, Jessica Patent: WO2011/48112 A1, 2011 ; WO 2011/048112 A1 Title/Abstract Full Text Show Details NOVARTIS AG Patent: US2012/196813 A1, 2012 ;
  • Route2
    • null|null
      129339-29-3
    • ~%
    • In-stock
      2,2-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine|CS-0111723
      866089-28-3

    References

    • NOVARTIS AG; BEBERNITZ, Gregory, Raymond; BOCK, Mark, G.; REDDY, Dumbala Srinivas; HAJARE, Atul Kashinath; VYAVAHARE, Vinod; BHOSALE, Sandeep Bhausaheb; KURHADE, Suresh Eknath; SALUNKHE, Videsh; SHAIKH, Nadim, S.; BHUNIYA, Debnath; PALLE, P., Venkata; FENG, Lili; LIANG, Jessica Patent: WO2011/48112 A1, 2011 ; WO 2011/048112 A1 Title/Abstract Full Text Show Details NOVARTIS AG Patent: US2012/196813 A1, 2012 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.2695
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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