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CS-W001157 4
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benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate

  • CAS No. 77211-75-7

  • Cat. No. CS-W000441
  • Purity≥95%
  • MDL No.MFCD11976640

*For research and further manufacturing use only, not for direct human use.

benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate|CS-W000441

Structure of 77211-75-7

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General Information

  • CAS No. 77211-75-7
  • Cat. No. CS-W000441
  • Purity ≥95%
  • MDL No. MFCD11976640
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₇NO₃
  • Molecular Weight 247.29
  • Synonym(s) 1-oxa-6-aza-spiro[2.5]octane-6-carboxylic acid benzyl ester
  • SMILES O=C(N1CCC2(CC1)OC2)OCc1ccccc1

Description

Benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate features a rigid spirocyclic core with complementary oxygen and nitrogen heteroatoms, enabling precise stereochemical control in asymmetric synthesis. The benzyl ester group offers convenient derivatization, while the scaffold exhibits excellent stability under standard reaction conditions.

Application

Benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate serves as a versatile spirocyclic building block in medicinal chemistry, enabling access to complex heterocyclic scaffolds. The protected amine and ester functionalities offer orthogonal reactivity, facilitating sequential transformations. Its robust bench stability and compatibility with standard coupling and reduction protocols make it well-suited for multi-step synthesis and scale-up applications.

Synthesis

  • Route1

    References

    • EP1619193 A1, ; Page/Page column 61 ; EP 1619193 A1

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅱ
Hazard Statements : H225-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P370+P378-P501

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Computational Chemistry Data

  • TPSA   42.07
  • LogP   2.188
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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