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CS-W001157 4
Total: USD 88.00

Cyclopropyl(4-fluorophenyl)methanone

  • CAS No. 772-31-6

  • Cat. No. CS-0155404
  • Purity≥97%
  • MDL No.MFCD00013728

*For research and further manufacturing use only, not for direct human use.

Cyclopropyl(4-fluorophenyl)methanone|CS-0155404

Structure of 772-31-6

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General Information

  • CAS No. 772-31-6
  • Cat. No. CS-0155404
  • Purity ≥97%
  • MDL No. MFCD00013728
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉FO
  • Molecular Weight 164.18
  • Synonym(s) Cyclopropyl 4-fluorophenyl ketone
  • SMILES C1CC1C(=O)C2=CC=C(C=C2)F

Description

Cyclopropyl(4-fluorophenyl)methanone features a cyclopropyl group attached to a carbonyl flanked by a para-fluorinated phenyl ring, delivering enhanced metabolic stability and lipophilicity. This scaffold integrates readily into bioactive molecules, enabling efficient access to pharmaceutical intermediates with improved membrane permeability and target engagement.

Application

Cyclopropyl(4-fluorophenyl)methanone serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard carbonyl transformations. Its cyclopropyl and 4-fluorophenyl moieties provide enhanced metabolic stability and modulated lipophilicity. The compound exhibits excellent bench stability and compatibility with common synthetic protocols, facilitating efficient amide formation, reduction, and nucleophilic addition reactions.

Synthesis

  • Route1

    References

    • Schliemann; Buege; Reppel Pharmazie, 1980 , vol. 35, # 3 p. 140 - 143
  • Route2
    • null|null
      5500-21-0
    • null|null
      460-00-4
    • ~%
    • In-stock
      Cyclopropyl(4-fluorophenyl)methanone|CS-0155404
      772-31-6

    References

    • Chemical Communications, , vol. 49, # 32 p. 3351 - 3353
  • Route3
    • null|null
      462-06-6
    • ~%
    • In-stock
      Cyclopropyl(4-fluorophenyl)methanone|CS-0155404
      772-31-6

    References

    • Pharmazie, , vol. 35, # 3 p. 140 - 143

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4184
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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