Lot numbers can be found on the outside label of a product:
6-Chloro-1H-indole-3-carboxylic acid
-
CAS No. 766557-02-2
- Cat. No. CS-W019457
- Purity≥98%
- MDL No.MFCD07776607
*For research and further manufacturing use only, not for direct human use.
Structure of 766557-02-2
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 766557-02-2
- Cat. No. CS-W019457
- Purity ≥98%
- MDL No. MFCD07776607
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₆ClNO₂
- Molecular Weight 195.60
- Synonym(s) 6-CHLOROINDOLE-3-CARBOXYLIC ACID
- SMILES O=C(C1=CNC2=C1C=CC(Cl)=C2)O
Description
6-Chloro-1H-indole-3-carboxylic acid integrates a chlorine substituent at the 6-position of the indole core, enhancing electronic properties for synthetic applications. This bench-stable carboxylic acid derivative serves as a key building block in medicinal chemistry and materials science, enabling direct coupling reactions without protection.
Application
6-Chloro-1H-indole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into indole-based scaffolds common in kinase inhibitors and CNS-active compounds. The carboxylic acid group facilitates straightforward amide coupling, esterification, or derivatization under standard conditions. Its chloro substituent at the 6-position provides moderate electron-withdrawing character and enhances metabolic stability, while maintaining bench stability and compatibility with diverse reaction environments.
Synthesis
-
Route1
-
676477-10-4 - ~96%
-
In-stock
766557-02-2
References
-
Bissantz, Caterina; Grundschober, Christophe; Ratni, Hasane; Rogers-Evans, Mark; Schnider, Patrick Patent: US2007/72888 A1, 2007 ; Location in patent: Page/Page column 14-15 ; US 20070072888 A1
-
-
Route2
-
In-stock
17422-33-2 - ~65%
-
In-stock
766557-02-2
References
-
Bissantz, Caterina; Grundschober, Christophe; Ratni, Hasane; Rogers-Evans, Mark; Schnider, Patrick Patent: US2007/155761 A1, 2007 ; Location in patent: Page/Page column 14 ; US 20070155761 A1
-
-
Route3
-
In-stock
703-82-2 - ~%
-
In-stock
766557-02-2
References
-
CrystEngComm, , vol. 15, # 37 p. 7490 - 7497
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 53.09
- LogP 2.5195
- H_Acceptors 1
- H_Donors 2
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 6-Chloro-1H-indole-3-carboxylic acid sigma6-Chloro-1H-indole-3-carboxylic acid manufacturer6-Chloro-1H-indole-3-carboxylic acid price6-Chloro-1H-indole-3-carboxylic acid structure6-Chloro-1H-indole-3-carboxylic acid SDSbuy 6-Chloro-1H-indole-3-carboxylic acid6-Chloro-1H-indole-3-carboxylic acid supplier6-Chloro-1H-indole-3-carboxylic acid uses6-Chloro-1H-indole-3-carboxylic acid molecular weightprice of 6-Chloro-1H-indole-3-carboxylic acid6-Chloro-1H-indole-3-carboxylic acid chemical name formula of 6-Chloro-1H-indole-3-carboxylic acid