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CS-W001157 4
Total: USD 88.00

3-Chloro-6-methylpicolinic acid

  • CAS No. 894074-82-9

  • Cat. No. CS-0063424
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Chloro-6-methylpicolinic acid|CS-0063424

Structure of 894074-82-9

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General Information

  • CAS No. 894074-82-9
  • Cat. No. CS-0063424
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) 3-Chloro-6-methyl-pyridine-2-carboxylic acid
  • SMILES O=C(C1=NC(C)=CC=C1Cl)O

Description

3-Chloro-6-methylpicolinic acid features a chlorinated pyridine core with a methyl group at the 6-position, delivering enhanced electron-withdrawing character and steric bulk. This combination improves metabolic stability and facilitates selective coupling in synthetic applications. The carboxylic acid functionality enables direct conjugation or derivatization under standard conditions.

Application

3-Chloro-6-methylpicolinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through standard coupling and cyclization reactions. Its ortho-chloro and methyl substituents provide enhanced reactivity and metabolic stability, while the carboxylic acid functionality facilitates direct derivatization or amide formation. The compound exhibits good bench stability and is readily purified by recrystallization, making it suitable for scale-up and routine synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.74162
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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