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CS-W001157 4
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1-Hydroxybut-2-yne

  • CAS No. 764-01-2

  • Cat. No. CS-B1382
  • Purity≥97%
  • MDL No.MFCD00002914

*For research and further manufacturing use only, not for direct human use.

1-Hydroxybut-2-yne|CS-B1382

Structure of 764-01-2

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General Information

  • CAS No. 764-01-2
  • Cat. No. CS-B1382
  • Purity ≥97%
  • MDL No. MFCD00002914
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆O
  • Molecular Weight 70.09
  • Synonym(s) Hydroxymethylmethylacetylene
  • SMILES CC#CCO

Description

2-Butyn-1-ol was used in the synthesis of homocoupling products, [{Ru(P(OCH3)3)2(CH3CN)3}2{-SCRCHCH(OCH2CCR)S}](CF3SO3)4.

Application

1-Hydroxybut-2-yne serves as a versatile building block in synthetic organic chemistry, enabling efficient access to α,β-unsaturated carbonyl systems via acid-catalyzed hydration or transition-metal-mediated transformations. Its terminal alkyne functionality facilitates Sonogashira coupling and cyclization reactions, while the hydroxyl group offers direct handle for derivatization. The compound exhibits sufficient bench stability for routine handling and purification, making it a practical choice for constructing complex scaffolds in medicinal chemistry and natural product synthesis.

Synthesis

  • Route1
    • null|null
      107-19-7
    • null|null
      74-88-4
    • ~92%
    • In-stock
      1-Hydroxybut-2-yne|CS-B1382
      764-01-2

    References

    • Audin, Patrick; Doutheau, Alain; Gore, Jacques Bulletin de la Societe Chimique de France, 1984 , vol. 2, # 7-8 p. 297 - 306
  • Route2
    • null|null
      83591-03-1
    • ~80%
    • In-stock
      1-Hydroxybut-2-yne|CS-B1382
      764-01-2

    References

    • Yu, Zhengkun; Verkade, John G. Journal of Organic Chemistry, 2000 , vol. 65, # 7 p. 2065 - 2068
  • Route3
    • null|null
      37428-46-9
    • ~49%
    • In-stock
      1-Hydroxybut-2-yne|CS-B1382
      764-01-2

    References

    • Kasymzhanova, M.; Abdukakharov, V. S.; Kamaev, F. G.; Abduvakhabov, A. A. Chemistry of Natural Compounds, 1989 , vol. 25, # 6 p. 708 - 713 Khimiya Prirodnykh Soedinenii, 1989 , # 6 p. 834 - 840

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Warning
UN#: 1987
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335-H412
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P273-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   0.002
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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