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CS-W001157 4
Total: USD 88.00

2-Bromopyridin-4-amine

  • CAS No. 7598-35-8

  • Cat. No. CS-W007377
  • Purity≥98%
  • MDL No.MFCD01646061

*For research and further manufacturing use only, not for direct human use.

2-Bromopyridin-4-amine|CS-W007377

Structure of 7598-35-8

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General Information

  • CAS No. 7598-35-8
  • Cat. No. CS-W007377
  • Purity ≥98%
  • MDL No. MFCD01646061
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BrN₂
  • Molecular Weight 173.01
  • Synonym(s) 4-Pyridinamine, 2-bromo-
  • SMILES C1=C(N)C=CN=C1Br

Description

2-Bromopyridin-4-amine features a bromine substituent at the 2-position and an amino group at the 4-position of the pyridine ring, creating a bifunctional platform for cross-coupling and nucleophilic substitution. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds and serves as a key intermediate in the synthesis of functionalized pharmaceuticals and agrochemicals.

Application

2-Bromopyridin-4-amine serves as a versatile building block in medicinal chemistry and catalytic synthesis. Its bromine atom enables palladium-catalyzed cross-coupling reactions, while the pyridin-4-amine functionality offers a handle for further derivatization via amide bond formation or metal coordination. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for use in modular scaffold construction and API development workflows.

Synthesis

  • Route1
    • null|null
      52092-43-0
    • ~99%
    • In-stock
      2-Bromopyridin-4-amine|CS-W007377
      7598-35-8

    References

    • Heterocycles, , vol. 75, # 1 p. 57 - 64
  • Route2
    • null|null
      52092-43-0
    • null|null
      7439-89-6
    • ~%
    • In-stock
      2-Bromopyridin-4-amine|CS-W007377
      7598-35-8

    References

    • US5929082 A1, ; US 5929082 A
  • Route3

    References

    • Bulletin des Societes Chimiques Belges, , vol. 97, # 1 p. 51 - 54

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.4263
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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