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Structure of 75815-75-7
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This pyrazole carboxylic acid features a trifluoromethyl-substituted phenyl ring, delivering enhanced electron-withdrawing character and metabolic stability. The conjugated system supports efficient coupling in peptide and macrocyclic synthesis, while the acidic proton enables salt formation for improved solubility in aqueous systems.
1-(3-(Trifluoromethyl)phenyl)-1H-pyrazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl aryl group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates amide bond formation and conjugation. The compound exhibits excellent bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis campaigns in drug discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: