dTAG Targeting Ligand 1

Name: dTAG Targeting Ligand 1
Brand: ChemScene
Availability: InStock
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CAS No. 755039-56-6
Cat. No. CS-M0330
Purity≥97%
MDL No.MFCD18207100

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

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Description

dTAG Targeting Ligand 1 delivers potent and selective engagement of target proteins for degradation via the dTAG system. This bifunctional molecule combines a high-affinity ligand with an E3 ubiquitin ligase recruiter, enabling efficient recruitment of the ubiquitin-proteasome machinery. Designed for robust in vivo and cellular applications, it facilitates precise protein depletion under standard conditions.

Application

dTAG Targeting Ligand 1 serves as a potent, cell-permeable degrader ligand that enables targeted protein degradation via the dTAG system. It functions as a high-affinity binder to the dTAG tag fused to target proteins, facilitating recruitment of the E3 ubiquitin ligase complex. The compound exhibits excellent bench stability, minimal off-target effects, and compatibility with standard cell-based assays, making it ideal for functional proteomics and target validation in drug discovery workflows.

General Information

CAS No. 755039-56-6
Cat. No. CS-M0330
Purity ≥97%
MDL No. MFCD18207100
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₂H₂₇N₅O₄
Molecular Weight 425.48
Synonym(s) None
SMILES O=C1[C@@H](CC)N(C2CCCC2)C3=NC(NC4=C(OC)C=C(C=C4)C(O)=O)=NC=C3N1C

Computational Chemistry Data

TPSA 107.89
LogP 3.431
H_Acceptors 7
H_Donors 2
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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dTAG Targeting Ligand 1

CAS No. 755039-56-6

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