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1-Bromo-4-iodo-2-methoxybenzene

  • CAS No. 755027-18-0

  • Cat. No. CS-0063934
  • Purity≥98%
  • MDL No.MFCD07780651

*For research and further manufacturing use only, not for direct human use.

1-Bromo-4-iodo-2-methoxybenzene|CS-0063934

Structure of 755027-18-0

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General Information

  • CAS No. 755027-18-0
  • Cat. No. CS-0063934
  • Purity ≥98%
  • MDL No. MFCD07780651
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrIO
  • Molecular Weight 312.93
  • Synonym(s) 2-Bromo-5-iodoanisole
  • SMILES COC1=CC(I)=CC=C1Br

Description

1-Bromo-4-iodo-2-methoxybenzene features a strategically positioned methoxy group that enhances solubility and directs electrophilic substitution, while the bromo and iodo substituents enable sequential cross-coupling reactions. This dual halogenated scaffold supports efficient Pd-catalyzed transformations in complex molecule synthesis.

Synthesis

  • Route1

    References

    • ABBOTT LABORATORIES Patent: WO2004/76424 A1, 2004 ; Location in patent: Page 79 ; WO 2004/076424 A1
  • Route2
    • In-stock
      2-Bromo-5-iodophenol|CS-0041106
      932372-99-1
    • null|null
      77-78-1
    • ~%
    • In-stock
      1-Bromo-4-iodo-2-methoxybenzene|CS-0063934
      755027-18-0

    References

    • Dabrowski, Marek; Kubicka, Joanna; Lulinski, Sergiusz; Serwatowski, Janusz Tetrahedron, 2005 , vol. 61, # 27 p. 6590 - 6595

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   3.0623
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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