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CS-W001157 4
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6-Bromo-2,3-dihydro-1H-inden-1-ol

  • CAS No. 75476-86-7

  • Cat. No. CS-0042135
  • Purity≥97%
  • MDL No.MFCD02916451

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2,3-dihydro-1H-inden-1-ol|CS-0042135

Structure of 75476-86-7

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General Information

  • CAS No. 75476-86-7
  • Cat. No. CS-0042135
  • Purity ≥97%
  • MDL No. MFCD02916451
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉BrO
  • Molecular Weight 213.07
  • Synonym(s) None
  • SMILES OC1CCC2=C1C=C(Br)C=C2

Description

6-Bromo-2,3-dihydro-1H-inden-1-ol features a brominated indenol scaffold with a hydroxyl group at the 1-position, offering a reactive handle for cross-coupling and functionalization. The molecule combines synthetic versatility with stability under standard bench conditions, enabling efficient integration into complex molecular architectures.

Application

6-Bromo-2,3-dihydro-1H-inden-1-ol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted indene derivatives. Its bromine functionality facilitates palladium-catalyzed cross-coupling reactions, while the secondary alcohol offers opportunities for selective derivatization. The compound exhibits good bench stability and compatibility with standard purification protocols, making it suitable for use in medicinal chemistry and materials synthesis workflows.

Synthesis

  • Route1

    References

    • Iwanowicz, Edwin J.; Watterson, Scott H.; Dhar, T.G. Murali; Pitts, William J.; Gu, Henry H. Patent: US2002/40022 A1, 2002 ;
  • Route2
    • 3-(4-Bromophenyl)acrylic acid Ozagrel Impurity|CS-0228823
      1200-07-3
    • ~%
    • In-stock
      6-Bromo-2,3-dihydro-1H-inden-1-ol|CS-0042135
      75476-86-7

    References

    • Matasi, Julius J.; Caldwell, John P.; Hao, Jinsong; Neustadt, Bernard; Arik, Leyla; Foster, Carolyn J.; Lachowicz, Jean; Tulshian, Deen B. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1333 - 1336
  • Route3

    References

    • Matasi, Julius J.; Caldwell, John P.; Hao, Jinsong; Neustadt, Bernard; Arik, Leyla; Foster, Carolyn J.; Lachowicz, Jean; Tulshian, Deen B. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1333 - 1336

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.4287
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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