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CS-W001157 4
Total: USD 88.00

Methyl 1-methylpyrrole-2-carboxylate

  • CAS No. 37619-24-2

  • Cat. No. CS-W011045
  • Purity≥97%
  • MDL No.MFCD00052747

*For research and further manufacturing use only, not for direct human use.

Methyl 1-methylpyrrole-2-carboxylate|CS-W011045

Structure of 37619-24-2

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General Information

  • CAS No. 37619-24-2
  • Cat. No. CS-W011045
  • Purity ≥97%
  • MDL No. MFCD00052747
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO₂
  • Molecular Weight 139.15
  • Synonym(s) Methyl-4-methylpyrrole-2-carboxylate
  • SMILES COC(=O)C1=CC=CN1C

Description

Methyl 1-methylpyrrole-2-carboxylate features a pyrrole ring bearing both methyl and ester functionalities at the 1- and 2-positions, respectively. This electron-rich heterocycle serves as a key scaffold in synthetic routes to bioactive molecules, offering enhanced solubility and stability under standard conditions. The ester group enables straightforward derivatization via hydrolysis or nucleophilic substitution, facilitating integration into complex architectures.

Application

Methyl 1-methylpyrrole-2-carboxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to pyrrole-based heterocycles and bioactive scaffolds. The ester functionality facilitates standard transformations such as hydrolysis, reduction, and coupling reactions, while the N-methylpyrrole core exhibits good bench stability and compatibility with diverse reaction conditions. Its defined regiochemistry supports predictable reactivity in electrophilic substitution and transition-metal-catalyzed processes, making it a reliable intermediate for medicinal chemistry and process development.

Synthesis

  • Route1
    • In-stock
      1-Methyl-2-pyrrolecarboxylic acid|CS-W013520
      6973-60-0
    • null|null
      74-88-4
    • ~92%
    • In-stock
      Methyl 1-methylpyrrole-2-carboxylate|CS-W011045
      37619-24-2

    References

    • Bailly; Pommery; Houssin; Henichart Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 11 p. 910 - 917
  • Route2
    • In-stock
      Methyl 1H-pyrrole-2-carboxylate|CS-W013518
      1193-62-0
    • null|null
      616-38-6
    • ~92%
    • In-stock
      Methyl 1-methylpyrrole-2-carboxylate|CS-W011045
      37619-24-2

    References

    • Laurila, Michael L.; Magnus, Nicholas A.; Staszak, Michael A. Organic Process Research and Development, 2009 , vol. 13, # 6 p. 1199 - 1201
  • Route3
    • null|null
      616-38-6
    • In-stock
      Pyrrole-2-carboxylic acid|CS-W001963
      634-97-9
    • ~79%
    • In-stock
      Methyl 1-methylpyrrole-2-carboxylate|CS-W011045
      37619-24-2

    References

    • Laurila, Michael L.; Magnus, Nicholas A.; Staszak, Michael A. Organic Process Research and Development, 2009 , vol. 13, # 6 p. 1199 - 1201

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   31.23
  • LogP   0.8117
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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