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CS-W001157 4
Total: USD 88.00

L-Prolinamide

  • CAS No. 7531-52-4

  • Cat. No. CS-D1209
  • Purity≥95%
  • MDL No.MFCD00005253

*For research and further manufacturing use only, not for direct human use.

L-Prolinamide|CS-D1209

Structure of 7531-52-4

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General Information

  • CAS No. 7531-52-4
  • Cat. No. CS-D1209
  • Purity ≥95%
  • MDL No. MFCD00005253
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀N₂O
  • Molecular Weight 114.15
  • Synonym(s) None
  • SMILES NC([C@H]1NCCC1)=O

Description

L-Prolinamide features a stable pyrrolidine ring with a primary amide functional group, offering enhanced solubility and reactivity in peptide synthesis. This configuration enables efficient coupling under standard conditions, while the amide moiety supports hydrogen bonding in catalytic and supramolecular applications.

Application

L-Prolinamide serves as a versatile chiral building block in synthetic organic chemistry, enabling stereoselective transformations through its amide functionality and constrained pyrrolidine ring. Its bench-stable nature and compatibility with common coupling conditions facilitate efficient peptide and heterocycle synthesis. Functions effectively as a catalyst precursor and scaffold component in medicinal chemistry applications requiring defined stereochemistry and moderate polarity.

Synthesis

  • Route1

    References

    • European Journal of Medicinal Chemistry, , vol. 44, # 7 p. 2807 - 2814
  • Route2
    • null|null
      929897-95-0
    • ~77%
    • In-stock
      L-Prolinamide|CS-D1209
      7531-52-4

    References

    • Journal of Organic Chemistry, , vol. 72, # 5 p. 1780 - 1784
  • Route3

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 35, # 7 p. 2810 - 2818

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   -0.7763
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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