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rel-((1R,2R)-2-Fluorocyclohexan-1-amine hydrochloride)

  • CAS No. 75198-16-2

  • Cat. No. CS-0038959
  • Purity≥95%
  • MDL No.MFCD27997390

*For research and further manufacturing use only, not for direct human use.

rel-((1R,2R)-2-Fluorocyclohexan-1-amine hydrochloride)|CS-0038959

Structure of 75198-16-2

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General Information

  • CAS No. 75198-16-2
  • Cat. No. CS-0038959
  • Purity ≥95%
  • MDL No. MFCD27997390
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃ClFN
  • Molecular Weight 153.63
  • Synonym(s) Trans-2-fluorocyclohexanaMine hydrochloride
  • SMILES F[C@H]1[C@H](N)CCCC1.Cl

Description

This fluorinated cyclohexamine scaffold delivers a rigid, stereodefined amine handle for asymmetric synthesis. The hydrochloride salt enhances solubility and stability under standard conditions, enabling reliable incorporation into chiral ligands and pharmaceutical intermediates.

Application

rel-((1R,2R)-2-Fluorocyclohexan-1-amine hydrochloride serves as a conformationally constrained, fluorinated amine building block for medicinal chemistry applications. Its stereochemistry enables predictable spatial orientation in target molecules, while the fluorine substituent enhances metabolic stability and modulates basicity. The hydrochloride salt ensures excellent solubility and bench stability, facilitating straightforward handling and purification in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.6476
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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