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CS-W001157 4
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Aminomalonamide

  • CAS No. 62009-47-6

  • Cat. No. CS-M1513
  • Purity≥97%
  • MDL No.MFCD00015932

*For research and further manufacturing use only, not for direct human use.

Aminomalonamide|CS-M1513

Structure of 62009-47-6

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General Information

  • CAS No. 62009-47-6
  • Cat. No. CS-M1513
  • Purity ≥97%
  • MDL No. MFCD00015932
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇N₃O₂
  • Molecular Weight 117.11
  • Synonym(s) NSC 75208; 2-Aminopropanediamide
  • SMILES O=C(N)C(N)C(N)=O

Description

Aminomalonamide features a reactive malonamide core paired with a primary amine group, enabling direct conjugation in bioconjugation workflows. This structure facilitates efficient coupling to carboxylated biomolecules under mild conditions, offering enhanced stability and selectivity in peptide and protein modification applications.

Application

Aminomalonamide serves as a versatile building block in medicinal chemistry, enabling the synthesis of diverse heterocyclic scaffolds through standard amide coupling and cyclization protocols. Its bifunctional nature—combining a primary amine and two adjacent carbonyl groups—facilitates efficient construction of pyrrolidine, piperidine, and other nitrogen-containing ring systems under mild conditions. The compound exhibits good bench stability and compatibility with common protecting group strategies, supporting scalable synthesis and purification via standard chromatographic or crystallization methods.

Synthesis

  • Route1

    References

    • BAYER PHARMACEUTICALS CORPORATION Patent: WO2007/64883 A2, 2007 ; Location in patent: Page/Page column 185 ;
  • Route2
    • Diethyl 2-aminomalonate|CS-0113084
      6829-40-9
    • ~99%
    • In-stock
      Aminomalonamide|CS-M1513
      62009-47-6

    References

    • IDENIX (CAYMAN) LIMITED; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Patent: WO2007/144686 A1, 2007 ; Location in patent: Page/Page column 129-130 ;
  • Route3
    • null|null
      69645-51-8
    • ~%
    • In-stock
      Aminomalonamide|CS-M1513
      62009-47-6

    References

    • Journal of the American Chemical Society, , vol. 36, p. 355

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   112.2
  • LogP   -2.7157
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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