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CS-W001157 4
Total: USD 88.00

2-(Thiazol-4-yl)acetic acid

  • CAS No. 7504-44-1

  • Cat. No. CS-0148809
  • Purity≥95%
  • MDL No.MFCD09991935

*For research and further manufacturing use only, not for direct human use.

2-(Thiazol-4-yl)acetic acid|CS-0148809

Structure of 7504-44-1

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General Information

  • CAS No. 7504-44-1
  • Cat. No. CS-0148809
  • Purity ≥95%
  • MDL No. MFCD09991935
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₂S
  • Molecular Weight None
  • Synonym(s) 4-Thiazoleacetic acid
  • SMILES O=C(O)CC1=CSC=N1

Description

2-(Thiazol-4-yl)acetic acid features a thiazole ring linked to an acetic acid side chain, delivering a rigid, electron-deficient heteroaromatic scaffold. This configuration supports integration into bioactive molecules and enables efficient conjugation in medicinal chemistry. The compound exhibits robust stability under standard conditions and facilitates direct functionalization at the carboxylic acid terminus.

Application

2-(Thiazol-4-yl)acetic acid serves as a versatile building block for medicinal chemistry and materials science, enabling efficient incorporation of the thiazole ring into bioactive scaffolds. Its carboxylic acid functionality facilitates direct coupling reactions, while the thiazolyl group offers enhanced metabolic stability and favorable pharmacophoric properties. The compound exhibits good bench stability and is compatible with standard peptide synthesis protocols, simplifying purification and integration into complex molecular architectures.

Synthesis

  • Route1

    References

    • Helvetica Chimica Acta, , vol. 28, p. 362,363 Journal of the Chemical Society, , p. 91
  • Route2

    References

    • Helvetica Chimica Acta, , vol. 28, p. 362,363
  • Route3

    References

    • Helvetica Chimica Acta, , vol. 28, p. 362,363

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H318-H412
Precautionary Statements : P273-P280-P305+P351+P338-P310-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.7702
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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