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CS-W001157 4
Total: USD 88.00

5-Bromo-3-fluoropyridin-2-amine

  • CAS No. 748812-37-5

  • Cat. No. CS-W018605
  • Purity≥96%
  • MDL No.MFCD11848483

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-fluoropyridin-2-amine|CS-W018605

Structure of 748812-37-5

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General Information

  • CAS No. 748812-37-5
  • Cat. No. CS-W018605
  • Purity ≥96%
  • MDL No. MFCD11848483
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BrFN₂
  • Molecular Weight 191.00
  • Synonym(s) None
  • SMILES BrC1=CN=C(C(=C1)F)N

Description

5-Bromo-3-fluoropyridin-2-amine features a strategically positioned bromine and fluorine substituent on a pyridine scaffold, enabling selective functionalization in cross-coupling reactions. The electron-deficient ring system enhances reactivity in palladium-catalyzed transformations, while the amine group serves as a direct handle for derivatization. This bench-stable intermediate is well-suited for medicinal chemistry and materials synthesis workflows.

Application

5-Bromo-3-fluoropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromine and fluorine substituents offer orthogonal functionalization potential, while the pyridin-2-amine moiety provides a robust nitrogen handle for derivatization. This compound exhibits excellent bench stability and facilitates efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P341-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.5654
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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