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CS-W001157 4
Total: USD 88.00

4-(2,4-Difluorophenoxy)benzoic acid

  • CAS No. 748183-47-3

  • Cat. No. CS-0095163
  • Molecule weight250.20
  • Purity≥98%
  • MDL No.MFCD11529198

*For research and further manufacturing use only, not for direct human use.

4-(2,4-Difluorophenoxy)benzoic acid|CS-0095163

Structure of 748183-47-3

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General Information

  • CAS No. 748183-47-3
  • Cat. No. CS-0095163
  • Purity ≥98%
  • MDL No. MFCD11529198
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₈F₂O₃
  • Molecular Weight 250.20
  • Synonym(s) None
  • SMILES O=C(O)C1=CC=C(OC2=CC=C(F)C=C2F)C=C1

Description

This 4-(2,4-difluorophenoxy)benzoic acid features a rigid aromatic core with strategically positioned fluorine atoms enhancing metabolic stability and lipophilicity. The carboxylic acid group enables direct conjugation or derivatization in pharmaceutical intermediates. Designed for use in bioactive molecule synthesis, it offers improved solubility and handling under standard bench conditions.

Application

4-(2,4-Difluorophenoxy)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmacologically relevant scaffolds. Its ortho-substituted phenoxy linkage provides enhanced metabolic stability, while the carboxylic acid functionality facilitates direct derivatization via amide, ester, or acyl transfer reactions. The molecule exhibits good bench stability and is readily purified by recrystallization, supporting its use in scalable synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   3.4553
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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