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CS-W001157 4
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2-(3,5-Diphenyl-1H-pyrazol-1-yl)acetic acid

  • CAS No. 93323-67-2

  • Cat. No. CS-0156360
  • Molecule weight278.31
  • Purity≥97%
  • MDL No.MFCD00299897

*For research and further manufacturing use only, not for direct human use.

2-(3,5-Diphenyl-1H-pyrazol-1-yl)acetic acid|CS-0156360

Structure of 93323-67-2

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General Information

  • CAS No. 93323-67-2
  • Cat. No. CS-0156360
  • Purity ≥97%
  • MDL No. MFCD00299897
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₄N₂O₂
  • Molecular Weight 278.31
  • Synonym(s) (3,5-Diphenyl-pyrazol-1-yl)-acetic acid
  • SMILES C1=CC=C(C=C1)C2=NN(CC(=O)O)C(=C2)C3=CC=CC=C3

Description

This pyrazole-based carboxylic acid integrates a sterically hindered diphenylpyrazole moiety with a reactive acetic acid handle, enabling direct conjugation in bioconjugation workflows. The electron-deficient pyrazole ring enhances stability under physiological conditions, while the pendant phenyl groups improve solubility in organic solvents.

Application

2-(3,5-Diphenyl-1H-pyrazol-1-yl)acetic acid serves as a versatile building block for pyrazole-based medicinal chemistry campaigns. Its carboxylic acid functionality enables direct amidation, esterification, or coupling reactions, while the 3,5-diphenylpyrazole core provides structural rigidity and enhanced lipophilicity. The compound exhibits good bench stability and facilitates efficient purification via standard recrystallization or chromatography, supporting scalable synthesis of functionalized heterocyclic scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P280-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   3.3017
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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