6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine

Name: 6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine
Brand: ChemScene
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CAS No. 746668-59-7
Cat. No. CS-0019302
Purity≥98%
MDL No.MFCD09038165

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6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine|CS-0019302

Structure of 746668-59-7

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General Information

CAS No. 746668-59-7
Cat. No. CS-0019302
Purity ≥98%
MDL No. MFCD09038165
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆BrN₃
Molecular Weight 212.05
Synonym(s) 6-bromo-5-methyl-[1,2,4]triazolo[1,5-a]pyridine
SMILES CC1=C(Br)C=CC2=NC=NN12

Description

6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine is a heterocyclic building block featuring a brominated triazolopyridine core with a methyl substituent at the 5-position. This scaffold offers enhanced stability and reactivity for coupling reactions, enabling efficient access to complex nitrogen-rich architectures in medicinal chemistry and materials science applications.

Application

6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions with high efficiency. The bromine substituent facilitates C–C bond formation under standard Suzuki, Stille, and Negishi conditions, while the methyl group enhances solubility and modulates electronic properties. Its bench-stable crystalline nature supports straightforward handling and purification, making it well-suited for medicinal chemistry campaigns and API intermediate synthesis.

Synthesis

Route1
- In-stock
  
  42753-71-9
- ~%
- In-stock
  
  746668-59-7
References
- Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3614 - 3627

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 30.19
LogP 1.80022
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Triazole compounds

Key Words

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6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine

CAS No. 746668-59-7

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