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CS-W001157 4
Total: USD 88.00

1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid

  • CAS No. 746658-74-2

  • Cat. No. CS-M0416
  • Purity≥98%
  • MDL No.MFCD09910215

*For research and further manufacturing use only, not for direct human use.

1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid|CS-M0416

Structure of 746658-74-2

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General Information

  • CAS No. 746658-74-2
  • Cat. No. CS-M0416
  • Purity ≥98%
  • MDL No. MFCD09910215
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₄
  • Molecular Weight 243.30
  • Synonym(s) (S)-1-(tert-Butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid
  • SMILES O=C(C1(C)N(C(OC(C)(C)C)=O)CCCC1)O

Description

This protected piperidine derivative features a tert-butoxycarbonyl group that enables stable incorporation into peptide syntheses. The methyl-substituted carboxylic acid moiety provides a rigid, electron-rich scaffold ideal for conformationally constrained analogs in medicinal chemistry.

Application

1-(tert-butoxycarbonyl)-2-methylpiperidine-2-carboxylic acid serves as a versatile building block for the synthesis of bioactive piperidine derivatives. The protected amine and carboxylic acid functionalities enable orthogonal functionalization, facilitating efficient peptide coupling and cyclization reactions. Its bench-stable tert-butyl carbamate group simplifies purification and provides excellent compatibility with standard synthetic protocols in medicinal chemistry and API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.2507
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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