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CS-W001157 4
Total: USD 88.00

3,5-Difluoropicolinic acid

  • CAS No. 745784-04-7

  • Cat. No. CS-W007725
  • Purity≥97%
  • MDL No.MFCD05664124

*For research and further manufacturing use only, not for direct human use.

3,5-Difluoropicolinic acid|CS-W007725

Structure of 745784-04-7

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General Information

  • CAS No. 745784-04-7
  • Cat. No. CS-W007725
  • Purity ≥97%
  • MDL No. MFCD05664124
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂NO₂
  • Molecular Weight 159.09
  • Synonym(s) 3,5-difluoropyridine-2-carbxylic acid
  • SMILES O=C(C1=NC=C(F)C=C1F)O

Description

3,5-Difluoropicolinic acid is a bench-stable, electron-deficient heteroaromatic carboxylic acid featuring fluorine substituents at the 3- and 5-positions of the pyridine ring. This strategic substitution enhances its utility in medicinal chemistry and materials science, where controlled reactivity and metabolic stability are critical.

Application

3,5-Difluoropicolinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds common in pharmaceutical development. Its ortho-fluorine substituents enhance metabolic stability and modulate electronic properties, while the carboxylic acid group facilitates direct coupling reactions or derivatization. Bench-stable and compatible with standard synthetic protocols, it functions effectively in peptide coupling, amide formation, and transition-metal-catalyzed transformations.

Synthesis

  • Route1

    References

    • EP2305672 A1, ; Page/Page column 79 ;

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.058
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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