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Methyl trans-3-amino-cyclobutanecarboxylate hydrochloride

  • CAS No. 74316-29-3

  • Cat. No. CS-0048879
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl trans-3-amino-cyclobutanecarboxylate hydrochloride|CS-0048879

Structure of 74316-29-3

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General Information

  • CAS No. 74316-29-3
  • Cat. No. CS-0048879
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO₂
  • Molecular Weight 165.62
  • Synonym(s) trans-Methyl 3-aminocyclobutanecarboxylate hydrochloride
  • SMILES Cl.COC(=O)[C@H]1C[C@H](N)C1

Description

Methyl trans-3-amino-cyclobutanecarboxylate hydrochloride features a rigid, conformationally constrained cyclobutane scaffold that stabilizes the amine orientation. This bench-stable derivative enables direct incorporation into peptide mimetics and bioactive scaffolds, offering enhanced metabolic resilience. The hydrochloride salt improves solubility and handling in aqueous reaction media.

Application

Methyl trans-3-amino-cyclobutanecarboxylate hydrochloride serves as a conformationally constrained amino acid surrogate, enabling the synthesis of bioactive peptidomimetics and heterocyclic scaffolds. Its stable trans configuration and protected amine facilitate selective functionalization, while the ester group supports derivatization via standard amidation or reduction protocols. The hydrochloride salt enhances solubility and handling, making it suitable for bench-scale applications in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.3185
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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