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6,7-Dihydroimidazo[1,2-a]pyrazin-8(5H)-one

  • CAS No. 740082-70-6

  • Cat. No. CS-0097179
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD09832032

*For research and further manufacturing use only, not for direct human use.

6,7-Dihydroimidazo[1,2-a]pyrazin-8(5H)-one|CS-0097179

Structure of 740082-70-6

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General Information

  • CAS No. 740082-70-6
  • Cat. No. CS-0097179
  • Purity ≥95%
  • MDL No. MFCD09832032
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇N₃O
  • Molecular Weight None
  • Synonym(s) Imidazo[1,2-a]pyrazin-8(5H)-one, 6,7-dihydro- (9CI)
  • SMILES O=C1C2=NC=CN2CCN1

Description

6,7-Dihydroimidazo[1,2-a]pyrazin-8(5H)-one is a heterocyclic scaffold featuring a fused imidazopyrazine core with saturated bonds at the 6,7-positions. This structure delivers enhanced solubility and metabolic stability compared to fully aromatic analogs. The compound serves as a privileged motif in medicinal chemistry, enabling efficient integration into kinase inhibitors and CNS-targeted therapeutics through its ability to form hydrogen-bonding interactions within biological binding sites.

Application

6,7-Dihydroimidazo[1,2-a]pyrazin-8(5H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient construction of fused nitrogen-containing systems. Its stability under standard reaction conditions and tolerance to diverse functional groups facilitate downstream derivatization. The core structure functions as a key building block for bioactive compounds, particularly in kinase inhibitor development, due to its ability to engage in hydrogen bonding and π-stacking interactions within target binding sites.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   46.92
  • LogP   -0.3735
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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