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CS-W001157 4
Total: USD 88.00

2-Methyl-4-pyrimidinamine

  • CAS No. 74-69-1

  • Cat. No. CS-W018583
  • Purity≥97%
  • MDL No.MFCD00626295

*For research and further manufacturing use only, not for direct human use.

2-Methyl-4-pyrimidinamine|CS-W018583

Structure of 74-69-1

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General Information

  • CAS No. 74-69-1
  • Cat. No. CS-W018583
  • Purity ≥97%
  • MDL No. MFCD00626295
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃
  • Molecular Weight 109.13
  • Synonym(s) 4-pyrimidinamine, 2-methyl-
  • SMILES NC1=NC(C)=NC=C1

Description

2-Methyl-4-pyrimidinamine is a bench-stable heterocyclic amine featuring a pyrimidine core with methyl and amino substituents at the 2- and 4-positions, respectively. This configuration imparts enhanced solubility in polar solvents and facilitates direct incorporation into medicinal chemistry scaffolds. The compound serves as a key intermediate in the synthesis of kinase inhibitors and nucleoside analogs due to its reactive nitrogen sites and favorable electronic profile.

Application

2-Methyl-4-pyrimidinamine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds. Its amino functionality facilitates nucleophilic substitution and coupling reactions, while the methyl group enhances metabolic stability. The compound exhibits good bench stability and compatibility with standard synthetic protocols, making it valuable for the construction of kinase inhibitors and other bioactive heterocycles.

Synthesis

  • Route1
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      1445-45-0
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      60838-50-8
    • ~73%
    • In-stock
      2-Methyl-4-pyrimidinamine|CS-W018583
      74-69-1

    References

    • Nishino, Shigeyoshi; Hirotsu, Kenji; Shima, Hidetaka; Harada, Takashi Patent: US2008/45712 A1, 2008 ; Location in patent: Page/Page column 3-4 ;
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 17, p. 1320,1322 Collection of Czechoslovak Chemical Communications, , vol. 14, p. 223,228 Chemische Berichte, , vol. 75, p. 760
  • Route3

    References

    • Chemische Berichte, , vol. 37, p. 3641

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.36722
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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