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5-(Methoxymethyl)-1H-pyrazol-3-amine

  • CAS No. 739366-03-1

  • Cat. No. CS-0050750
  • Purity≥97%
  • MDL No.MFCD22576523

*For research and further manufacturing use only, not for direct human use.

5-(Methoxymethyl)-1H-pyrazol-3-amine|CS-0050750

Structure of 739366-03-1

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General Information

  • CAS No. 739366-03-1
  • Cat. No. CS-0050750
  • Purity ≥97%
  • MDL No. MFCD22576523
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉N₃O
  • Molecular Weight None
  • Synonym(s) 1H-Pyrazol-3-amine,5-(methoxymethyl)-(9CI)
  • SMILES COCC1=CC(N)=NN1

Description

5-(Methoxymethyl)-1H-pyrazol-3-amine features a pyrazole core functionalized with a methoxymethyl group at C5 and an amino substituent at C3, delivering enhanced solubility and synthetic versatility. This scaffold integrates readily into bioactive molecules, enabling efficient access to pharmacologically relevant heterocycles under standard conditions.

Application

5-(Methoxymethyl)-1H-pyrazol-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazole-based scaffolds. Its methoxymethyl group provides orthogonal handle for selective derivatization, while the primary amine facilitates coupling reactions. The compound exhibits excellent bench stability and is compatible with standard protection/deprotection sequences, making it well-suited for modular synthesis of bioactive heterocycles.

Synthesis

  • Route1
    • 4-Methoxy-3-oxobutanenitrile|CS-0580214
      739366-02-0
    • ~51%
    • In-stock
      5-(Methoxymethyl)-1H-pyrazol-3-amine|CS-0050750
      739366-03-1

    References

    • SANWA KAGAKU KENKYUSHO CO., LTD. Patent: EP1595866 A1, 2005 ; Location in patent: Page/Page column 16 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.93
  • LogP   0.1383
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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