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5-Chloro-3H-[1,2,3]triazolo[4,5-b]pyridine

  • CAS No. 73895-37-1

  • Cat. No. CS-0156754
  • Purity≥97%
  • MDL No.MFCD18258955

*For research and further manufacturing use only, not for direct human use.

5-Chloro-3H-[1,2,3]triazolo[4,5-b]pyridine|CS-0156754

Structure of 73895-37-1

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General Information

  • CAS No. 73895-37-1
  • Cat. No. CS-0156754
  • Purity ≥97%
  • MDL No. MFCD18258955
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₄
  • Molecular Weight 154.56
  • Synonym(s) 5-Chloro-1H-[1,2,3]triazolo[4,5-b]pyridine
  • SMILES C1=CC(=NC2=C1N=NN2)Cl

Description

5-Chloro-3H-[1,2,3]triazolo[4,5-b]pyridine is a heterocyclic scaffold featuring a chlorinated triazolopyridine core with enhanced electron-deficient character. This structure integrates readily into medicinal chemistry campaigns, serving as a stable, high-affinity bioisostere in kinase inhibitor and CNS-targeted drug discovery.

Application

5-Chloro-3H-[1,2,3]triazolo[4,5-b]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and agrochemical research. Its chlorine substituent enables direct cross-coupling reactions and nucleophilic substitution pathways, facilitating the construction of complex triazolopyridine scaffolds. The molecule exhibits good bench stability and functional group tolerance, supporting efficient derivatization in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.46
  • LogP   1.0063
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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