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CS-W001157 4
Total: USD 88.00

4-Piperidineacetic acid hydrochloride

  • CAS No. 73415-84-6

  • Cat. No. CS-W001879
  • Purity≥97%
  • MDL No.MFCD03414187

*For research and further manufacturing use only, not for direct human use.

4-Piperidineacetic acid hydrochloride|CS-W001879

Structure of 73415-84-6

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General Information

  • CAS No. 73415-84-6
  • Cat. No. CS-W001879
  • Purity ≥97%
  • MDL No. MFCD03414187
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄ClNO₂
  • Molecular Weight 179.64
  • Synonym(s) None
  • SMILES Cl.O=C(O)CC1CCNCC1

Description

4-Piperidineacetic acid hydrochloride offers a stable, moisture-tolerant platform for synthesizing bioactive compounds. The piperidine ring integrates seamlessly into pharmaceutical scaffolds, while the acetic acid moiety enables direct conjugation or derivatization under standard conditions. This salt form enhances solubility and handling in aqueous reaction systems.

Application

4-Piperidineacetic acid hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of piperidine-containing scaffolds prevalent in bioactive molecules. Its carboxylic acid functionality facilitates direct coupling reactions, while the protonated piperidine nitrogen enhances solubility and stability in aqueous media. The hydrochloride salt form ensures excellent bench stability and ease of handling, making it well-suited for peptide coupling, macrocyclization, and derivatization workflows in drug discovery.

Synthesis

  • Route1

    References

    • Pryde, David C.; Corless, Martin; Fenwick, David R.; Mason, Helen J.; Stammen, Blanda C.; Stephenson, Peter T.; Ellis, David; Bachelor, David; Gordon, David; Barber, Christopher G.; Wood, Anthony; Middleton, Donald S.; Blakemore, David C.; Parsons, Gemma C.; Eastwood, Rachel; Platts, Michelle Y.; Statham, Keith; Paradowski, Kerry A.; Burt, Catherine; Klute, Wolfgang Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1084 - 1088
  • Route2
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      35081-79-9
    • ~%
    • In-stock
      4-Piperidineacetic acid hydrochloride|CS-W001879
      73415-84-6

    References

    • European Journal of Medicinal Chemistry, , vol. 17, # 6 p. 531 - 535
  • Route3
    • null|null
      84839-49-6
    • ~%
    • In-stock
      4-Piperidineacetic acid hydrochloride|CS-W001879
      73415-84-6

    References

    • European Journal of Medicinal Chemistry, , vol. 17, # 6 p. 531 - 535

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   0.8825
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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