tert-Butyl 3-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxylate

Name: tert-Butyl 3-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 733757-77-2
Cat. No. CS-0055301
Purity≥95%
MDL No.None

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tert-Butyl 3-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxylate|CS-0055301

Structure of 733757-77-2

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General Information

CAS No. 733757-77-2
Cat. No. CS-0055301
Purity ≥95%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₉N₃O₂
Molecular Weight 237.30
Synonym(s) Tert-butyl 3-methyl-6,7-dihydro-1H-pyrazolo[4,3-C]pyridine-5(4H)-carboxylate
SMILES CC1=C2CN(CCC2=NN1)C(=O)OC(C)(C)C

Description

tert-Butyl 3-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxylate is a bench-stable, moisture-tolerant heterocyclic building block featuring a fused pyrazolo[4,3-c]pyridine core. This compound integrates a tert-butyl ester group at the C5 position and a methyl substituent at C3, enabling direct functionalization in late-stage diversification. The electron-deficient aromatic system facilitates transition-metal-catalyzed coupling reactions and supports efficient access to bioactive pyrazolopyridine scaffolds.

Application

tert-Butyl 3-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxylate serves as a versatile building block for the synthesis of pyrazolopyridine-based scaffolds. The tert-butyl ester group enables facile deprotection under mild acidic conditions, while the methyl substituent at C3 supports site-specific functionalization. Its stability and compatibility with standard coupling reactions make it ideal for medicinal chemistry campaigns targeting kinase inhibitors and other bioactive heterocycles.

Synthesis

Route1
- In-stock
  
  157327-43-0
- ~%
- In-stock
  
  733757-77-2
References
- SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu Patent: WO2013/71697 A1, 2013 ; Location in patent: Paragraph 00388 ;
Route2
- In-stock
  
  24424-99-5
- ~%
- In-stock
  
  733757-77-2
References
- SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu Patent: WO2013/71697 A1, 2013 ;
Route3
- 109384-19-2
- ~%
- In-stock
  
  733757-77-2
References
- SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu Patent: WO2013/71697 A1, 2013 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 58.22
LogP 2.01132
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

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tert-Butyl 3-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxylate

CAS No. 733757-77-2

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