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CS-W001157 4
Total: USD 88.00

4,6-Dichloropyridin-3-amine

  • CAS No. 7321-93-9

  • Cat. No. CS-W002550
  • Purity≥98%
  • MDL No.MFCD00234054

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloropyridin-3-amine|CS-W002550

Structure of 7321-93-9

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General Information

  • CAS No. 7321-93-9
  • Cat. No. CS-W002550
  • Purity ≥98%
  • MDL No. MFCD00234054
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄Cl₂N₂
  • Molecular Weight 163.01
  • Synonym(s) Pyridin-3-amine, 4,6-dichloro-
  • SMILES Clc1ncc(c(c1)Cl)N

Description

4,6-Dichloropyridin-3-amine features a pyridine core with strategically positioned chlorine atoms that enhance electrophilic reactivity at the 3-amine site. This electron-deficient heterocycle serves as a key scaffold in medicinal chemistry, enabling efficient coupling reactions for constructing bioactive molecules. Bench-stable and moisture-tolerant, it streamlines synthesis workflows in process development.

Application

4,6-Dichloropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. The ortho-dichloro substitution pattern facilitates sequential functionalization, while the pyridin-3-amine moiety offers direct engagement in nucleophilic displacement and amide bond formation. Bench-stable and readily purified, it functions reliably in multistep synthesis workflows for API development.

Synthesis

  • Route1

    References

    • Boehringer Ingelheim International GmbH Patent: US2006/217417 A1, 2006 ; Location in patent: Page/Page column 13 ;
  • Route2

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 69, p. 673,690
  • Route3

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 69, p. 673,690

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.9706
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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