Lot numbers can be found on the outside label of a product:
6-Chloro-9-(2-tetrahydropyranyl)purine
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CAS No. 7306-68-5
- Cat. No. CS-M3457
- Purity≥98%
- MDL No.MFCD00022821
*For research and further manufacturing use only, not for direct human use.
Structure of 7306-68-5
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General Information
- CAS No. 7306-68-5
- Cat. No. CS-M3457
- Purity ≥98%
- MDL No. MFCD00022821
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₁ClN₄O
- Molecular Weight 238.67
- Synonym(s) 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine; 9-(Tetrahydropyran-2-yl)-6-chloropurine; NSC 33187; 6-chloro-9-tetrahydro-2-pyranyl-purine
- SMILES ClC1=NC=NC2=C1N=CN2C3OCCCC3
Description
6-Chloro-9-(2-tetrahydropyranyl)purine serves as a protected purine scaffold for nucleoside synthesis, featuring a labile tetrahydropyranyl group at the 9-position. This protecting group enables selective functionalization under mild conditions while maintaining stability during standard reaction protocols. The chloro substituent at C6 imparts enhanced reactivity in cross-coupling processes and facilitates downstream derivatization.
Application
6-Chloro-9-(2-tetrahydropyranyl)purine serves as a versatile purine scaffold for medicinal chemistry and heterocyclic synthesis. The 6-chloro group enables nucleophilic substitution reactions, while the 2-tetrahydropyranyl protecting group ensures stability and orthogonality during multi-step transformations. This compound facilitates efficient access to functionalized purine derivatives with enhanced solubility and handling characteristics, making it ideal for iterative synthetic campaigns in drug discovery.
Synthesis
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Route1
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110-87-2 -
In-stock
87-42-3 - ~99%
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In-stock
7306-68-5
References
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AMGEN INC. Patent: WO2008/153947 A2, 2008 ; Location in patent: Page/Page column 41; 61 ; WO 2008/153947 A2
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Route2
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110-87-2
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1336-21-6
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In-stock
87-42-3
- ~78%
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In-stock
7306-68-5
References
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Ortho Pharmaceutical Corporation Patent: US4876257 A1, 1989 ; Title/Abstract Full Text Show Details Ortho Pharmaceutical Corporation Patent: US5164390 A1, 1992 ;
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Route3
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In-stock
68-94-0 - ~%
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In-stock
7306-68-5
References
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Organic and Biomolecular Chemistry, , vol. 2, # 5 p. 665 - 670
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 52.83
- LogP 2.1788
- H_Acceptors 5
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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