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CS-W001157 4
Total: USD 88.00

2-Fluoro-5-nitrobenzoic acid

  • CAS No. 7304-32-7

  • Cat. No. CS-W007433
  • Purity≥97%
  • MDL No.MFCD00134238

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-nitrobenzoic acid|CS-W007433

Structure of 7304-32-7

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General Information

  • CAS No. 7304-32-7
  • Cat. No. CS-W007433
  • Purity ≥97%
  • MDL No. MFCD00134238
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄FNO₄
  • Molecular Weight 185.11
  • Synonym(s) BUTTPARK 32\01-76
  • SMILES O=C(O)C1=CC([N+]([O-])=O)=CC=C1F

Description

2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product.2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid supportsynthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenolsin the synthesis of oxazepines

Synthesis

  • Route1

    References

    • KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN RandD; UNIVERSITE DE LILLE; CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE; ECOLE NATIONALE SUPERIEURE DE CHIMIE DE LILLE; BAILLY, Fabrice; BILLAMBOZ, Muriel; CHRIST, Frauke; COTELLE, Philippe; DEBYSER, Zeger; LION, Cedric; SUCHAUD, Virginie Patent: WO2012/85003 A1, 2012 ; Location in patent: Page/Page column 83 ; WO 2012/085003 A1
  • Route2

    References

    • Bulletin des Societes Chimiques Belges, , vol. 39, p. 101
  • Route3
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    • In-stock
      2-Fluoro-5-nitrobenzoic acid|CS-W007433
      7304-32-7

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 33, p. 336

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   80.44
  • LogP   1.4321
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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