(2-Fluoro-5-nitrophenyl)methanol

Name: (2-Fluoro-5-nitrophenyl)methanol
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CAS No. 63878-73-9
Cat. No. CS-0157662
Molecule weight171.13
Purity≥98%
MDL No.MFCD02683502

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(2-Fluoro-5-nitrophenyl)methanol|CS-0157662

Structure of 63878-73-9

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General Information

CAS No. 63878-73-9
Cat. No. CS-0157662
Purity ≥98%
MDL No. MFCD02683502
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆FNO₃
Molecular Weight 171.13
Synonym(s) Benzenemethanol, 2-fluoro-5-nitro-
SMILES C1=C(C=C(CO)C(=C1)F)[N+](=O)[O-]

Description

(2-Fluoro-5-nitrophenyl)methanol features a fluorinated aromatic ring paired with a nitro group at the para position, delivering enhanced electrophilicity and stability. This configuration enables efficient coupling reactions in synthetic pathways, particularly in the construction of bioactive heterocycles and pharmaceutical intermediates under standard conditions.

Application

(2-Fluoro-5-nitrophenyl)methanol serves as a versatile building block in medicinal chemistry, enabling direct introduction of both fluorine and nitro functionality adjacent to a benzylic alcohol. Its bench-stable nature and compatibility with standard transformations—such as nucleophilic substitution, reduction of the nitro group, and derivatization of the alcohol—facilitate efficient access to diverse heterocyclic scaffolds and functionalized aryl intermediates.

Synthesis

Route1
- In-stock
  
  27996-87-8
- ~99%
- In-stock
  
  63878-73-9
References
- Le Fur, Nicolas; Larchanche, Paul-Emmanuel; Melnyk, Patricia Heterocyclic Communications, 2010 , vol. 16, # 4-6 p. 235 - 239
Route2
- In-stock
  
  7304-32-7
- ~96%
- In-stock
  
  63878-73-9
References
- Chugai Seiyaku Kabushiki Kaisha Patent: US6534546 B1, 2003 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 63.37
LogP 1.2262
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(2-Fluoro-5-nitrophenyl)methanol

CAS No. 63878-73-9

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