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CS-W001157 4
Total: USD 88.00

1-(4-Chlorophenyl)cyclopropanecarboxylic acid

  • CAS No. 72934-37-3

  • Cat. No. CS-W010578
  • Purity≥97%
  • MDL No.MFCD00001289

*For research and further manufacturing use only, not for direct human use.

1-(4-Chlorophenyl)cyclopropanecarboxylic acid|CS-W010578

Structure of 72934-37-3

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General Information

  • CAS No. 72934-37-3
  • Cat. No. CS-W010578
  • Purity ≥97%
  • MDL No. MFCD00001289
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉ClO₂
  • Molecular Weight 196.63
  • Synonym(s) 1-(p-Chlorophenyl)cyclopropanecarboxylic acid
  • SMILES OC(=O)C1(CC1)C1=CC=C(Cl)C=C1

Description

1-(4-Chlorophenyl)cyclopropanecarboxylic acid features a rigid cyclopropane ring fused to a para-chlorophenyl group, delivering enhanced metabolic stability and defined spatial orientation. This structural motif enables precise molecular recognition in target-directed synthesis and serves as a key scaffold in medicinal chemistry for bioactive compound development.

Application

1-(4-Chlorophenyl)cyclopropanecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive cyclopropyl-containing scaffolds. Its stability and compatibility with standard coupling reactions facilitate efficient peptide and heterocyclic extension. The ortho-substituted aryl group enhances metabolic resilience, while the carboxylic acid functionality supports direct derivatization or salt formation for improved solubility and purification.

Synthesis

  • Route1

    References

    • RELIANCE LIFE SCIENCES PVT. LTD. Patent: WO2009/150660 A1, 2009 ; Location in patent: Page/Page column 16 ;
  • Route2

    References

    • Chemische Berichte, , vol. 112, p. 3914 - 3933

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.4562
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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