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CS-W001157 4
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1-(3-Chlorophenyl)cyclopropanecarboxylic acid

  • CAS No. 124276-34-2

  • Cat. No. CS-0038546
  • Molecule weight196.63
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(3-Chlorophenyl)cyclopropanecarboxylic acid|CS-0038546

Structure of 124276-34-2

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General Information

  • CAS No. 124276-34-2
  • Cat. No. CS-0038546
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉ClO₂
  • Molecular Weight 196.63
  • Synonym(s) 1-(3-chlorophenyl)cyclopropane-1-carboxylic acid
  • SMILES C1=CC(=CC(=C1)C2(CC2)C(=O)O)Cl

Description

This cyclopropanecarboxylic acid derivative features a 3-chlorophenyl group attached to the cyclopropyl ring, delivering enhanced lipophilicity and metabolic stability. The carboxylic acid functionality enables direct coupling in peptide synthesis or derivatization for medicinal chemistry applications. Designed for robust performance under standard bench conditions, this compound serves as a key building block in bioactive molecule development.

Application

1-(3-Chlorophenyl)cyclopropanecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard functional group manipulations. Its cyclopropane core imparts conformational rigidity, while the ortho-chlorinated aryl moiety offers enhanced metabolic stability and favorable pharmacokinetic properties. The carboxylic acid functionality facilitates direct coupling reactions, esterification, or amide formation, supporting efficient route development for API candidates. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.4562
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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