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CS-W001157 4
Total: USD 88.00

2-Chloro-5-thiophenecarboxaldehyde

  • CAS No. 7283-96-7

  • Cat. No. CS-W002227
  • Purity≥97%
  • MDL No.MFCD00047090

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-thiophenecarboxaldehyde|CS-W002227

Structure of 7283-96-7

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General Information

  • CAS No. 7283-96-7
  • Cat. No. CS-W002227
  • Purity ≥97%
  • MDL No. MFCD00047090
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClOS
  • Molecular Weight 146.59
  • Synonym(s) 5-Chloro-2-thiophenecarboxaldehyde
  • SMILES O=CC1=CC=C(S1)Cl

Application

2-Chloro-5-thiophenecarboxaldehyde serves as a versatile building block for the synthesis of thiophene-based heterocycles and bioactive molecules. Its aldehyde functionality enables efficient imine formation, reductive amination, and coupling reactions, while the chloro substituent offers orthogonal reactivity for cross-coupling protocols. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1
    • null|null
      96-43-5
    • null|null
      68-12-2
    • ~53%
    • In-stock
      2-Chloro-5-thiophenecarboxaldehyde|CS-W002227
      7283-96-7

    References

    • Liegault, Benoit; Petrov, Ivan; Gorelsky, Serge I.; Fagnou, Keith Journal of Organic Chemistry, 2010 , vol. 75, # 4 p. 1047 - 1060
  • Route2
    • null|null
      96-43-5
    • ~%
    • In-stock
      2-Chloro-5-thiophenecarboxaldehyde|CS-W002227
      7283-96-7

    References

    • US5145868 A1, ;
  • Route3
    • null|null
      96-43-5
    • null|null
      93-61-8
    • ~%
    • In-stock
      2-Chloro-5-thiophenecarboxaldehyde|CS-W002227
      7283-96-7

    References

    • Journal of the American Chemical Society, , vol. 72, p. 1422 Journal of Organic Chemistry, , vol. 13, p. 635,637 US2741622 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.214
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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