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CS-W001157 4
Total: USD 88.00

5-Bromo-1H-indole-2-carboxylic acid

  • CAS No. 7254-19-5

  • Cat. No. CS-W007593
  • Purity≥98%
  • MDL No.MFCD00022705

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1H-indole-2-carboxylic acid|CS-W007593

Structure of 7254-19-5

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General Information

  • CAS No. 7254-19-5
  • Cat. No. CS-W007593
  • Purity ≥98%
  • MDL No. MFCD00022705
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆BrNO₂
  • Molecular Weight 240.06
  • Synonym(s) None
  • SMILES O=C(C(N1)=CC2=C1C=CC(Br)=C2)O

Application

5-Bromo-1H-indole-2-carboxylic acid serves as a versatile building block for the synthesis of indole-based pharmaceuticals and agrochemicals. The carboxylic acid group enables direct coupling reactions, while the bromine substituent facilitates palladium-catalyzed cross-couplings, including Suzuki and Heck reactions. Its bench-stable solid form and predictable reactivity support efficient functionalization in multi-step synthetic sequences.

Synthesis

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    References

    • La Regina, Giuseppe; Sarkar, Taradas; Bai, Ruoli; Edler, Michael C.; Saletti, Roberto; Coluccia, Antonio; Piscitelli, Francesco; Minelli, Lara; Gatti, Valerio; Mazzoccoli, Carmela; Palermo, Vanessa; Mazzoni, Cristina; Falcone, Claudio; Scovassi, Anna Ivana; Giansanti, Vincenzo; Campiglia, Pietro; Porta, Amalia; Maresca, Bruno; Hamel, Ernest; Brancale, Andrea; Novellino, Ettore; Silvestri, Romano Journal of Medicinal Chemistry, 2009 , vol. 52, # 23 p. 7512 - 7527
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    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 24 p. 4385 - 4388
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      17403-17-7
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    • In-stock
      5-Bromo-1H-indole-2-carboxylic acid|CS-W007593
      7254-19-5

    References

    • Journal of Organic Chemistry, , vol. 20, p. 1458

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   2.6286
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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