2,4-Dichloro-6,7-dimethoxyquinoline

Name: 2,4-Dichloro-6,7-dimethoxyquinoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 72407-17-1
Cat. No. CS-0052159
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4-Dichloro-6,7-dimethoxyquinoline|CS-0052159

Structure of 72407-17-1

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General Information

CAS No. 72407-17-1
Cat. No. CS-0052159
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₉Cl₂NO₂
Molecular Weight 258.10
Synonym(s) 2,4-dichloro-6,7-dimethoxy-quinoline
SMILES COC1=C(OC)C=C2C(Cl)=CC(Cl)=NC2=C1

Description

2,4-Dichloro-6,7-dimethoxyquinoline features a sterically hindered quinoline core with electron-donating methoxy groups flanking a chlorine-substituted heterocyclic scaffold. This configuration enhances stability and enables selective coupling in transition-metal-catalyzed transformations. The molecule integrates readily into advanced synthetic intermediates for pharmaceutical and agrochemical development under standard conditions.

Application

2,4-Dichloro-6,7-dimethoxyquinoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinoline-based scaffolds through palladium-catalyzed cross-coupling reactions. The dichloro substitution pattern facilitates sequential functionalization, while the dimethoxy groups provide enhanced solubility and stability under standard reaction conditions. Its bench-stable nature and compatibility with diverse coupling partners make it ideal for modular synthesis of bioactive molecules and pharmaceutical intermediates.

Synthesis

Route1
- 141-82-2
- In-stock
  
  6315-89-5
- ~%
- In-stock
  
  72407-17-1
References
- SYNTA PHARMACEUTICALS, CORP. Patent: WO2005/46698 A1, 2005 ; Location in patent: Page/Page column 93; 94 ;
Route2
- 412335-39-8
- ~82%
- In-stock
  
  72407-17-1
References
- Ahvale, Appasaheb B.; Prokopcova, Hana; Sefcovicova, Jana; Steinschifter, Waltraud; Taeubl, Anna E.; Uray, Georg; Stadlbauer, Wolfgang European Journal of Organic Chemistry, 2008 , # 3 p. 563 - 571

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 31.35
LogP 3.5588
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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2,4-Dichloro-6,7-dimethoxyquinoline

CAS No. 72407-17-1

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