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CS-W001157 4
Total: USD 88.00

Amino-PEG5-amine

  • CAS No. 72236-26-1

  • Cat. No. CS-0107954
  • Purity≥97%
  • MDL No.MFCD07369626

*For research and further manufacturing use only, not for direct human use.

Amino-PEG5-amine|CS-0107954

Structure of 72236-26-1

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General Information

  • CAS No. 72236-26-1
  • Cat. No. CS-0107954
  • Purity ≥97%
  • MDL No. MFCD07369626
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₈N₂O₅
  • Molecular Weight 280.36
  • Synonym(s) None
  • SMILES NCCOCCOCCOCCOCCOCCN

Description

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.Methylglyoxal solution has been used:to assess glyoxalase 1 (GLO1) enzymatic activityas an advanced glycation end (AGE) forming agent for the preparation of albumin in vitroto regulate anxiety like behavior in miceto induce peritoneal fibrosis in ratsto study the chromatographic retention characteristics of organic chemicals and metal DNA adductsfor intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

Synthesis

  • Route1

    References

    • LaFrate, Andrew L.; Carlson, Kathryn E.; Katzenellenbogen, John A. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3528 - 3535
  • Route2
    • Bis[2-[2-(2-chloroethoxy)ethoxy]ethyl]ether|CS-0622238
      52559-90-7
    • ~%
    • In-stock
      Amino-PEG5-amine|CS-0107954
      72236-26-1

    References

    • EP882016 B1, ;
  • Route3

    References

    • Angewandte Chemie - International Edition, , vol. 44, # 34 p. 5441 - 5447

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   98.19
  • LogP   -1.0132
  • H_Acceptors   7
  • H_Donors   2
  • Rotatable_Bonds   16

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