Fmoc-D-Orn(Dde)-OH

Name: Fmoc-D-Orn(Dde)-OH
Brand: ChemScene
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CAS No. 1419640-31-5
Cat. No. CS-0173477
Purity≥98%
MDL No.MFCD02094127

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-D-Orn(Dde)-OH is a protected amino acid derivative designed for solid-phase peptide synthesis. The Fmoc group enables orthogonal deprotection, while the Dde moiety on the side chain provides selective removal under mild conditions. This combination facilitates efficient incorporation of D-ornithine into complex sequences with minimal epimerization and high fidelity.

Application

Fmoc-D-Orn(Dde)-OH serves as a key building block in solid-phase peptide synthesis, enabling the incorporation of D-ornithine with orthogonal protection. The Fmoc group allows for mild deprotection under basic conditions, while the Dde (1,3-dimethylbutyl) side chain protection is selectively removed via hydrazinolysis, facilitating sequential coupling and site-specific modifications. Its stability during handling and compatibility with standard peptide synthesis protocols make it ideal for constructing complex peptidomimetics and cyclic peptides.

General Information

CAS No. 1419640-31-5
Cat. No. CS-0173477
Purity ≥98%
MDL No. MFCD02094127
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₀H₃₄N₂O₆
Molecular Weight 518.60
Synonym(s) N5-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]ornithine
SMILES C/C(NCCC[C@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=C4C(CC(C)(CC/4=O)C)=O

Computational Chemistry Data

TPSA 121.8
LogP 4.5803
H_Acceptors 6
H_Donors 3
Rotatable_Bonds 9

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Non-protein amino acids

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-Orn(Dde)-OH

CAS No. 1419640-31-5

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