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CS-W001157 4
Total: USD 88.00

(3-Chloro-2-fluorophenyl)methanamine

  • CAS No. 72235-55-3

  • Cat. No. CS-0119900
  • Purity≥95%
  • MDL No.MFCD01631391

*For research and further manufacturing use only, not for direct human use.

(3-Chloro-2-fluorophenyl)methanamine|CS-0119900

Structure of 72235-55-3

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General Information

  • CAS No. 72235-55-3
  • Cat. No. CS-0119900
  • Purity ≥95%
  • MDL No. MFCD01631391
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClFN
  • Molecular Weight 159.59
  • Synonym(s) 3-Chloro-2-fluorobenzylamine
  • SMILES NCC1=CC=CC(Cl)=C1F

Description

(3-Chloro-2-fluorophenyl)methanamine is a fluorinated arylalkylamine featuring ortho-chloro and meta-fluoro substitution on the phenyl ring. This electron-deficient aromatic scaffold enables efficient coupling in cross-coupling and amide-forming reactions. The primary amine group offers direct functionalization potential, while the halogenated framework enhances metabolic stability and lipophilicity in bioactive molecule design.

Application

(3-Chloro-2-fluorophenyl)methanamine serves as a valuable building block for bioactive heterocycles and pharmaceutical intermediates, enabling direct incorporation of ortho-fluoro-chloro aryl motifs. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of functionalized anilines, pyridines, and fused ring systems relevant to medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P280-P301+P330+P331-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.9378
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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