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CS-W001157 4
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(2-Chloro-3-fluorophenyl)methanamine

  • CAS No. 72235-54-2

  • Cat. No. CS-0139216
  • Purity≥98%
  • MDL No.MFCD10687077

*For research and further manufacturing use only, not for direct human use.

(2-Chloro-3-fluorophenyl)methanamine|CS-0139216

Structure of 72235-54-2

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General Information

  • CAS No. 72235-54-2
  • Cat. No. CS-0139216
  • Purity ≥98%
  • MDL No. MFCD10687077
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClFN
  • Molecular Weight 159.59
  • Synonym(s) 2-CHLORO-3-FLUORO-BENZYLAMINE
  • SMILES NCC1=CC=CC(F)=C1Cl

Description

(2-Chloro-3-fluorophenyl)methanamine features a dual halogenated aromatic core enabling precise functionalization in medicinal chemistry. This bench-stable, moisture-tolerant amine integrates readily into bioactive scaffolds, delivering enhanced metabolic stability and targeted receptor engagement in CNS-directed drug discovery programs.

Application

(2-Chloro-3-fluorophenyl)methanamine serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-chloro and meta-fluoro substituents enable selective functionalization and enhance metabolic stability in drug candidates. The primary amine facilitates straightforward derivatization via amidation, alkylation, or reductive amination, while maintaining bench stability and ease of purification.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.9378
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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