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Structure of 72235-51-9
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(2,3-Difluorophenyl)methanamine is a bench-stable arylalkylamine featuring two fluorine atoms at the ortho and meta positions of the phenyl ring. This electron-deficient aromatic system enhances metabolic stability while maintaining favorable solubility for use in medicinal chemistry. The primary amine group enables direct incorporation into diverse molecular architectures via coupling reactions, making it a valuable scaffold for drug discovery.
(2,3-Difluorophenyl)methanamine serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles and drug-like scaffolds. Its difluorinated aromatic core enhances metabolic stability and modulates lipophilicity, while the primary amine facilitates straightforward derivatization via amidation, alkylation, or reductive amination. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it well-suited for iterative synthesis and lead optimization workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 2735
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H227-H314
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: