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CS-W001157 4
Total: USD 88.00

3-Chloro-4-methylpyridine

  • CAS No. 72093-04-0

  • Cat. No. CS-W011140
  • Purity≥98%
  • MDL No.MFCD04114245

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-methylpyridine|CS-W011140

Structure of 72093-04-0

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General Information

  • CAS No. 72093-04-0
  • Cat. No. CS-W011140
  • Purity ≥98%
  • MDL No. MFCD04114245
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClN
  • Molecular Weight None
  • Synonym(s) 3-CHLORO-4-PICOLINE
  • SMILES ClC1=C(C=CN=C1)C

Description

3-Chloro-4-methylpyridine is a bench-stable, electron-deficient heterocycle featuring a chlorine atom at the 3-position and a methyl group at the 4-position. This configuration enables selective functionalization in cross-coupling reactions and facilitates incorporation into pharmaceutical intermediates requiring tailored electronic properties.

Application

3-Chloro-4-methylpyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its electrophilic halogen and activating methyl group. The chlorine atom facilitates efficient functionalization under standard Suzuki, Negishi, or Buchwald–Hartwig conditions, while the pyridine nitrogen provides coordination for transition metal catalysts. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.

Synthesis

  • Route1
    • null|null
      108-89-4
    • ~%
    • In-stock
      3-Chloro-4-methylpyridine|CS-W011140
      72093-04-0
    • In-stock
      3,5-Dichloro-4-Picoline|CS-W000393
      100868-46-0

    References

    • Journal of Organic Chemistry, , vol. 26, p. 789
  • Route2
    • In-stock
      3-Chloropyridine|CS-W011253
      626-60-8
    • null|null
      74-88-4
    • ~%
    • In-stock
      3-Chloro-4-methylpyridine|CS-W011140
      72093-04-0
    • 3-Chloro-4-ethylpyridine|CS-0672197
      79698-48-9

    References

    • Journal of Organometallic Chemistry, , vol. 216, # 2 p. 139 - 147
  • Route3
    • null|null
      38113-08-5
    • ~%
    • In-stock
      3-Chloro-4-methylpyridine|CS-W011140
      72093-04-0

    References

    • DE946802 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.04342
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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