2-Chloro-5-methoxypyridin-3-amine

Name: 2-Chloro-5-methoxypyridin-3-amine
Brand: ChemScene
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CAS No. 720666-45-5
Cat. No. CS-0005559
Purity≥98%
MDL No.MFCD11044248

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-methoxypyridin-3-amine|CS-0005559

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General Information

CAS No. 720666-45-5
Cat. No. CS-0005559
Purity ≥98%
MDL No. MFCD11044248
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) 3-Amino-2-chloro-5-methoxypyridine
SMILES NC1=CC(OC)=CN=C1Cl

Description

2-Chloro-5-methoxypyridin-3-amine features a pyridine core functionalized with chlorine, methoxy, and amine groups, enabling selective coupling in medicinal chemistry. The electron-deficient ring facilitates nucleophilic substitution, while the amine handles serve as anchor points for diversification. This scaffold offers stability under standard conditions and compatibility with common transition-metal-catalyzed reactions.

Application

2-Chloro-5-methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloropyridine moiety. The methoxy and amino groups provide orthogonal functional handles for further derivatization, while the compound exhibits excellent bench stability and compatibility with standard purification methods. It functions as a key intermediate in the synthesis of heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 48.14
LogP 1.3258
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-methoxypyridin-3-amine

CAS No. 720666-45-5

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